The effect of combined TPF and intensity modulated radiotherapy after TPF induction chemotherapy on locally advanced nasopharyngeal carcinoma: a retrospective analysis

نویسندگان

چکیده

BACKGROUND To evaluate the efficacy and toxicity of docetaxel, cisplatin, fluorouracil (TPF) regimen followed by intensity modulated radiotherapy (IMRT) on locally advanced nasopharyngeal carcinoma (NPC). METHODS A total 150 patients with NPC [American Joint Committee Cancer (AJCC) 2009 stage IIIa-IVb] received 2 or 3 cycles a TPF as induction chemotherapy. group 67 participants (TPF group) continued to receive chemotherapy radiotherapy, remaining 83 (P cisplatin radiotherapy. RESULTS median follow-up 35 months (4-66 months) showed that there was no significant difference between P in progression-free survival (PFS) overall (OS). The incidence rate myelosuppression at 3-4 degrees 16.9% 34.3% (P=0.029), respectively, oral mucosa reaction 18.1% 37.3% group, respectively (P=0.007). 3-4-degree skin 15.7% 29.9% (P=0.030), respectively. liver function injury significantly lower than (P<0.05). CONCLUSIONS Compared concurrent IMRT improvement OS PFS NPC, but exhibited more severe hematologic toxicity, mucosal responses, reactions, functional impairment.

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ژورنال

عنوان ژورنال: Annals of palliative medicine

سال: 2021

ISSN: ['2224-5839', '2224-5820']

DOI: https://doi.org/10.21037/apm-21-2073